Robust epidemiological data to monitor progress of the elimination of hepatitis C virus (HCV) infection are needed. The European Centre for Disease Prevention and Control contracted the Robert Koch Institute (RKI) to develop a protocol for undertaking HCV prevalence surveys in the general population under SPHERE-C. We aimed at piloting the stand-alone survey design, one of three designs covered in the protocol, in Stara Zagora, the 6th largest city in Bulgaria.